Cobalt(ii)-catalyzed chelation-assisted C–H iodination of aromatic amides with I2

Abstract

The cobalt-catalyzed chelation-assisted iodination of aromatic amides using molecular I₂ as an iodinating reagent is reported. 8-Amino-5-chloroquinoline functions as an efficient directing group. This mild and air stable catalytic system shows a wide functional group tolerance and improved synthetic accessibility.