Issue 16, 2018
From the journal:

Chemical Communications

Supramolecular protein cages constructed from a crystalline protein matrix†

Hashiru Negishi,a   Satoshi Abe, ORCID logo *a   Keitaro Yamashita, ORCID logo b   Kunio Hirata,bc   Kento Niwase,a   Marion Boudes,d   Fasséli Coulibaly, ORCID logo d   Hajime Morie  and  Takafumi Ueno ORCID logo *a  

* Corresponding authors

a School of Life Science and Technology, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
E-mail: saabe@bio.titech.ac.jp, tueno@bio.titech.ac.jp

b SR Life Science Instrumentation Unit, RIKEN/SPring-8 Center, 1-1-1, Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan

c Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

d Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia

e Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

Abstract

Protein crystals are formed via ordered arrangements of proteins, which assemble to form supramolecular structures. Here, we show a method for the assembly of supramolecular protein cages within a crystalline environment. The cages are stabilized by covalent cross-linking allowing their release via dissolution of the crystal. The high stability of the desiccated protein crystals allows cages to be constructed.

Graphical abstract: Supramolecular protein cages constructed from a crystalline protein matrix

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Article information

DOI
https://doi.org/10.1039/C7CC08689J
Article type
Communication
Submitted
11 Nov 2017
Accepted
29 Jan 2018
First published
29 Jan 2018

Chem. Commun., 2018,54, 1988-1991

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Supramolecular protein cages constructed from a crystalline protein matrix

H. Negishi, S. Abe, K. Yamashita, K. Hirata, K. Niwase, M. Boudes, F. Coulibaly, H. Mori and T. Ueno, Chem. Commun., 2018, 54, 1988 DOI: 10.1039/C7CC08689J

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