Issue 15, 2018
From the journal:

Chemical Communications

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action†

Michael D. Wallace,a   Nidda F. Waraich,b   Aleksandra W. Debowski, ORCID logo ac   Maxime G. Corral,ad   Anthony Maxwell, ORCID logo b   Joshua S. Mylne ORCID logo *ad  and  Keith A. Stubbs ORCID logo *a  

* Corresponding authors

a School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
E-mail: keith.stubbs@uwa.edu.au, joshua.mylne@uwa.edu.au

b Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, UK

c School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia

d ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA 6009, Australia

Abstract

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

Graphical abstract: Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

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Article information

DOI
https://doi.org/10.1039/C7CC09518J
Article type
Communication
Submitted
12 Dec 2017
Accepted
24 Jan 2018
First published
25 Jan 2018

Chem. Commun., 2018,54, 1869-1872

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Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

M. D. Wallace, N. F. Waraich, A. W. Debowski, M. G. Corral, A. Maxwell, J. S. Mylne and K. A. Stubbs, Chem. Commun., 2018, 54, 1869 DOI: 10.1039/C7CC09518J

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