In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

Zhimei He; Yan Xiao; Jian-Rong Zhang; Penghui Zhang; Jun-Jie Zhu

doi:10.1039/C7CC09532E

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In situ formation of large pore silica–MnO₂ nanocomposites with H⁺/H₂O₂ sensitivity for O₂-elevated photodynamic therapy and potential MR imaging†

Zhimei He,

‡^a Yan Xiao,‡^a Jian-Rong Zhang,

*^ab Penghui Zhang*^ac and Jun-Jie Zhu

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, China
E-mail: jjzhu@nju.edu.cn

^b School of Chemistry and Life Science, Nanjing University Jinling College, Nanjing 210089, China

^c The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, China

Abstract

A cancer cell-specific, endogenous H⁺/H₂O₂-activated, and O₂ self-sufficient nanocomposite is engineered and characterized. Such NPs, with good biocompatibility and rapid response to intracellular H⁺/H₂O₂, have demonstrated improved therapeutic effects in targeted cancer cells and activated MR signals in vitro, providing a promising strategy for effective PDT against tumor hypoxia.

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Article information

DOI: https://doi.org/10.1039/C7CC09532E
Article type: Communication
Submitted: 13 Dec 2017
Accepted: 24 Jan 2018
First published: 24 Jan 2018

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Chem. Commun., 2018,54, 2962-2965

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In situ formation of large pore silica–MnO₂ nanocomposites with H⁺/H₂O₂ sensitivity for O₂-elevated photodynamic therapy and potential MR imaging

Z. He, Y. Xiao, J. Zhang, P. Zhang and J. Zhu, Chem. Commun., 2018, 54, 2962 DOI: 10.1039/C7CC09532E

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