Issue 19, 2018
From the journal:

Chemical Communications

Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(iii) complexes†

Kangqiang Qiu,‡a   Libing Ke,‡a   Xuepeng Zhang,b   Yukang Liu,a   Thomas W. Rees,a   Liangnian Ji,a   Jiajie Diao ORCID logo *c  and  Hui Chao ORCID logo *ad  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: ceschh@mail.sysu.edu.cn

b Lab of Computational and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China

c Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
E-mail: jiajie.diao@uc.edu

d MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China

Abstract

Two iridium(III) complexes with ligands containing morpholine groups were used to track mitochondrial pH fluctuation during cell apoptosis as their emissive intensities linearly increased with increase in pH values.

Graphical abstract: Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(iii) complexes

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Article information

DOI
https://doi.org/10.1039/C8CC00299A
Article type
Communication
Submitted
13 Jan 2018
Accepted
13 Feb 2018
First published
13 Feb 2018

Chem. Commun., 2018,54, 2421-2424

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Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes

K. Qiu, L. Ke, X. Zhang, Y. Liu, T. W. Rees, L. Ji, J. Diao and H. Chao, Chem. Commun., 2018, 54, 2421 DOI: 10.1039/C8CC00299A

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