The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3

Wen Zhou; Mohammad Almeqdadi; Michael E. Xifaras; Imogen A. Riddell; Ömer H. Yilmaz; Stephen J. Lippard

doi:10.1039/C8CC00393A

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The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃†

Wen Zhou,

^ab Mohammad Almeqdadi,

^b Michael E. Xifaras,

^b Imogen A. Riddell,

‡^a Ömer H. Yilmaz*^b and Stephen J. Lippard

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
E-mail: lippard@mit.edu

^b The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Tehcnology, Cambridge, MA 02139, USA
E-mail: ohyilmaz@mit.edu

Abstract

A trans-DDP based monofunctional phenanthridine Pt(II) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

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DOI: https://doi.org/10.1039/C8CC00393A
Article type: Communication
Submitted: 17 Jan 2018
Accepted: 14 Feb 2018
First published: 27 Feb 2018
This article is Open Access

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Chem. Commun., 2018,54, 2788-2791

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The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃

W. Zhou, M. Almeqdadi, M. E. Xifaras, I. A. Riddell, Ö. H. Yilmaz and S. J. Lippard, Chem. Commun., 2018, 54, 2788 DOI: 10.1039/C8CC00393A

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