We present a novel strategy for the discrimination of single nucleotide variants (SNVs) by combining cooperativity with sequestration, which displays remarkably high specificity (discrimination factors ranging from 67 to 618 with a median of 194) against 12 model SNVs and can be easily integrated with PCR amplification to detect KRAS G12D mutation.
S. Hu, N. Li and F. Liu, Chem. Commun., 2018, 54, 3223 DOI: 10.1039/C8CC00838H
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