Issue 35, 2018

Combining photoredox and silver catalysis for azidotrifluoromethoxylation of styrenes

Abstract

The first example of an azidotrifluoromethoxylation of styrenes has been achieved by synergistic visible-light-mediated photoredox and silver catalysis. Trifluoromethyl arylsulfonate (TFMS) and the Zhdankin reagent were used as the trifluoromethoxylation reagent and the azide source, respectively. A good functional group tolerance and mild reaction conditions of this method are applicable to late-stage azidotrifluoromethoxylation of complex small molecules. Furthermore, the mechanistic investigations indicate the single-electron transfer involved in the reaction.

Graphical abstract: Combining photoredox and silver catalysis for azidotrifluoromethoxylation of styrenes

Supplementary files

Article information

Article type
Communication
Submitted
08 Feb 2018
Accepted
09 Apr 2018
First published
09 Apr 2018

Chem. Commun., 2018,54, 4473-4476

Combining photoredox and silver catalysis for azidotrifluoromethoxylation of styrenes

F. Cong, Y. Wei and P. Tang, Chem. Commun., 2018, 54, 4473 DOI: 10.1039/C8CC01096J

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