Issue 26, 2018
From the journal:

Chemical Communications

A novel iridium(iii) complex for sensitive HSA phosphorescence staining in proteome research†

Yi Wang, ORCID logo a   Huaiyi Huang,b   Ge Chen,a   Haijie Chen,a   Tingting Xu,a   Qian Tang,a   Hailiang Zhu,*c   Qianling Zhang ORCID logo a  and  Pingyu Zhang ORCID logo *a  

* Corresponding authors

a College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, P. R. China
E-mail: p.zhang6@szu.edu.cn

b Department of Chemistry, University of Warwick, Coventry, UK

c State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, P. R. China

Abstract

We report a novel organo-iridium(III) complex (Ir1) for the selective and sensitive determination of human serum albumin (HSA). The phosphorescence of Ir1 is turned-on by HSA in the urinary system. Importantly, Ir1 is much simpler and less time-consuming for HSA staining than Coomassie blue in proteomics studies.

Graphical abstract: A novel iridium(iii) complex for sensitive HSA phosphorescence staining in proteome research

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Article information

DOI
https://doi.org/10.1039/C8CC01597J
Article type
Communication
Submitted
26 Feb 2018
Accepted
05 Mar 2018
First published
06 Mar 2018

Chem. Commun., 2018,54, 3282-3285

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A novel iridium(III) complex for sensitive HSA phosphorescence staining in proteome research

Y. Wang, H. Huang, G. Chen, H. Chen, T. Xu, Q. Tang, H. Zhu, Q. Zhang and P. Zhang, Chem. Commun., 2018, 54, 3282 DOI: 10.1039/C8CC01597J

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