A highly regio- and diastereo-selective ortho-lithiation/addition of anisoles to N-tert-butanesulfinyl imines resulting in the selective formation of chiral α-branched amines is described. This method is also efficient for highly regioselective benzylic lithiation of o-methylanisoles, followed by diastereoselective addition to N-tert-butanesulfinyl imines.
L. R. Reddy, S. Kotturi, Y. Waman, C. Patel, A. Patwa and R. Shenoy, Chem. Commun., 2018, 54, 7007 DOI: 10.1039/C8CC03764G
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