Issue 51, 2018
From the journal:

Chemical Communications

Dehydroxylation of alcohols for nucleophilic substitution†

Jia Chen,a   Jin-Hong Lin ORCID logo a  and  Ji-Chang Xiao*a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: jchxiao@sioc.ac.cn

Abstract

The Ph3P/ICH2CH2I system-promoted dehydroxylative substitution of alcohols was achieved to construct C–O, C–N, C–S and C–X (X = Cl, Br, and I) bonds. Compared with the previous approaches such as the Appel reaction and Mitsunobu reaction, this protocol offers some practical advantages such as safe operation and a convenient amination process.

Graphical abstract: Dehydroxylation of alcohols for nucleophilic substitution

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Article information

DOI
https://doi.org/10.1039/C8CC03856B
Article type
Communication
Submitted
14 May 2018
Accepted
30 May 2018
First published
30 May 2018

Chem. Commun., 2018,54, 7034-7037

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Dehydroxylation of alcohols for nucleophilic substitution

J. Chen, J. Lin and J. Xiao, Chem. Commun., 2018, 54, 7034 DOI: 10.1039/C8CC03856B

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