Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
A. Ou, A. Guédin, B. W. Skelton, S. Amrane, C. W. Evans, M. Norret, K. S. Iyer, J. Mergny and N. M. Smith, Chem. Commun., 2018, 54, 9647 DOI: 10.1039/C8CC03945C
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