Issue 77, 2018
From the journal:

Chemical Communications

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs†

Ka Lung Chan, ORCID logo ‡a   Boya Peng, ORCID logo ‡b   Mubarak I. Umar, ORCID logo a   Chun-Yin Chan, ORCID logo a   Aleksandr B. Sahakyan, ORCID logo c   Minh T. N. Le ORCID logo *b  and  Chun Kit Kwok ORCID logo *a  

* Corresponding authors

a Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China
E-mail: ckkwok42@cityu.edu.hk

b Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China
E-mail: mle.bms@cityu.edu.hk

c MRC WIMM Centre for Computational Biology, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

Abstract

Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA–mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

Graphical abstract: Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

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Article information

DOI
https://doi.org/10.1039/C8CC04635B
Article type
Communication
Submitted
11 Jun 2018
Accepted
25 Aug 2018
First published
27 Aug 2018

Chem. Commun., 2018,54, 10878-10881

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Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

K. L. Chan, B. Peng, M. I. Umar, C. Chan, A. B. Sahakyan, M. T. N. Le and C. K. Kwok, Chem. Commun., 2018, 54, 10878 DOI: 10.1039/C8CC04635B

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