Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation

Abstract

Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-β (Aβ) aggregation with a high inhibition rate of 0.64–0.86. This research provides a new perspective on the design of chiral Aβ inhibitors using supramolecular metal–organic cages.