Hydrogen sulfide induced supramolecular self-assembly in living cells

Abstract

Here we developed a critical gasotransmitter (H₂S) mediated reduction to induce supramolecular self-assembly in multiple living cell lines. Specifically, the reduction converted an azido group to an amine which allowed the formation of intramolecular hydrogen bonds. The hydrogen bonds planarized the assembling molecules and promoted the supramolecular self-assembly.