Issue 68, 2018
From the journal:

Chemical Communications

Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity†

Hien Bao Dieu Thai,ab   Fabienne Levi-Acobas,c   Soo-Young Yum, ORCID logo d   Goo Jang,d   Marcel Hollenstein ORCID logo c  and  Dae-Ro Ahn ORCID logo *ab  

* Corresponding authors

a Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Korea
E-mail: drahn@kist.re.kr

b Division of Biomedical Science and Technology, KIST School, Korea University of Science and Technology (UST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Korea

c Laboratory for Bioorganic Chemistry of Nucleic Acids, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3523, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France

d Department of Veterinary Clinical Science, College of Veterinary Medicine and BK21 PLUS Program for Creative Veterinary Science Research, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 151-747, Korea

Abstract

We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.

Graphical abstract: Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

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Article information

DOI
https://doi.org/10.1039/C8CC05721D
Article type
Communication
Submitted
15 Jul 2018
Accepted
20 Jul 2018
First published
23 Jul 2018

Chem. Commun., 2018,54, 9410-9413

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Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

H. B. D. Thai, F. Levi-Acobas, S. Yum, G. Jang, M. Hollenstein and D. Ahn, Chem. Commun., 2018, 54, 9410 DOI: 10.1039/C8CC05721D

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