Issue 83, 2018
From the journal:

Chemical Communications

Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection†

Tatsuya Nishihara, ORCID logo *a   Satoshi Kuno,b   Hiroshi Nonaka, ORCID logo b   Sho Tabata,a   Natsumi Saito,c   Shinji Fukuda,adef   Masaru Tomita,a   Shinsuke Sando ORCID logo bg  and  Tomoyoshi Soga*a  

* Corresponding authors

a Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Yamagata 997-0052, Tsuruoka, Japan
E-mail: nishi-t@ttck.keio.ac.jp, soga@sfc.keio.ac.jp

b Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

c National Institute of Technology, Tsuruoka College, 104 Sawada, Inooka, Tsuruoka, Yamagata 997-8511, Japan

d Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan

e Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Tsukuba, Japan

f PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Saitama 332-0012, Kawaguchi, Japan

g Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Abstract

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

Graphical abstract: Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

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Article information

DOI
https://doi.org/10.1039/C8CC06068A
Article type
Communication
Submitted
26 Jul 2018
Accepted
17 Sep 2018
First published
26 Sep 2018

Chem. Commun., 2018,54, 11745-11748

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Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

T. Nishihara, S. Kuno, H. Nonaka, S. Tabata, N. Saito, S. Fukuda, M. Tomita, S. Sando and T. Soga, Chem. Commun., 2018, 54, 11745 DOI: 10.1039/C8CC06068A

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