Visible-light photocatalytic bicyclization of β-alkynyl propenones for accessing diastereoenriched syn-fluoren-9-ones†
Shu-Jiang
Tu 
*a
and
Bo
Jiang
*a
*a
and
Bo
Jiang
*a
Abstract
A novel visible-light photocatalytic bicyclization of β-alkynyl propenones with α-bromocarbonyls for highly diastereoselective synthesis of richly decorated syn-fluoren-9-ones is described. The reaction proceeds via a radical-triggered 5-exo-dig cyclization/1,6-H-abstraction/6-endo-trig cyclization cascade and offers a new and practical method for the assembly of 6/5/6 carbocyclic skeletons via C(sp3)–H alkenylation.
- This article is part of the themed collection: Organic Synthesis
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