Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

Oleksii Shemchuk; Lixing Song; Koen Robeyns; Dario Braga; Fabrizia Grepioni; Tom Leyssens

doi:10.1039/C8CC06199H

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl₂†

Oleksii Shemchuk,

^a Lixing Song,^b Koen Robeyns,

^b Dario Braga,

^a Fabrizia Grepioni

*^a and Tom Leyssens*^b

Author affiliations

* Corresponding authors

^a Molecular Crystal Engineering Laboratory, Dipartimento di Chimica “G. Ciamician”, Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy
E-mail: fabrizia.grepioni@unibo.it

^b Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, 1 Place Louis Pasteur, B-1348 Louvain-La-Neuve, Belgium
E-mail: tom.leyssens@uclouvain.be

Abstract

Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl₂. Depending on the amount of ZnCl₂ either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl₂ triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl₂/solvent phase diagram.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C8CC06199H
Article type: Communication
Submitted: 30 Jul 2018
Accepted: 03 Sep 2018
First published: 06 Sep 2018

Download Citation

Chem. Commun., 2018,54, 10890-10892

Permissions

Request permissions

Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl₂

O. Shemchuk, L. Song, K. Robeyns, D. Braga, F. Grepioni and T. Leyssens, Chem. Commun., 2018, 54, 10890 DOI: 10.1039/C8CC06199H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications