Towards rational design of RAD51-targeting prodrugs: platinumIV–artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells

Shuren Zhang; Hao Yuan; Yan Guo; Kun Wang; Xiaoyong Wang; Zijian Guo

doi:10.1039/C8CC06576D

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Towards rational design of RAD51-targeting prodrugs: platinum^IV–artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells†

Shuren Zhang,^a Hao Yuan,^a Yan Guo,^a Kun Wang,^a Xiaoyong Wang

*^b and Zijian Guo

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
E-mail: zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 89684549

^b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China
E-mail: boxwxy@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 89684549

Abstract

Two Pt^IV–artesunate anticancer prodrugs that target RAD51, a crucial protein in homologous recombination mediating the sensitivity of cancer cells to DNA-damaging agents, were designed; their cytotoxicities against BRCA-proficient ovarian and breast cancer cells are significantly higher than those of cisplatin.

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Article information

DOI: https://doi.org/10.1039/C8CC06576D
Article type: Communication
Submitted: 13 Aug 2018
Accepted: 11 Sep 2018
First published: 11 Sep 2018

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Chem. Commun., 2018,54, 11717-11720

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Towards rational design of RAD51-targeting prodrugs: platinum^IV–artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells

S. Zhang, H. Yuan, Y. Guo, K. Wang, X. Wang and Z. Guo, Chem. Commun., 2018, 54, 11717 DOI: 10.1039/C8CC06576D

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