Issue 93, 2018
From the journal:

Chemical Communications

Asynchrony of spectral blue-shifts of quantum dot based digital homogeneous immunoassay†

Xiaojun Liu,‡a   Conghui Huang,‡a   Xiuling Dong,b   Aiye Liang,c   Yusu Zhang,a   Qingquan Zhang,a   Qi Wang*d  and  Hongwei Gai ORCID logo *a  

* Corresponding authors

a School of Chemistry and Materials Science, Jiangsu Normal University, Shanghai Road 101, Xuzhou, Jiangsu, China
E-mail: gai@jsnu.edu.cn

b Oncology Treatment Centre, Hangzhou Hekang Rehabilitation Hospital, Hangzhou, Zhejiang, China

c Department of Physical Sciences, Charleston Southern University, North Charleston, SC, USA

d Department of Respiratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, P. R. China
E-mail: wqdlmu@163.com

Abstract

A femtomolar digital homogenous immunoassay is developed based on sensitively distinguishing the immunocomplexes labeled with quantum dot (QD) aggregates from the excessive free monodisperse single QDs. The success in quantifying the carcino-embryonic antigen and alpha-fetoprotein in plasma validated the feasibility of our approach for clinical tests.

Graphical abstract: Asynchrony of spectral blue-shifts of quantum dot based digital homogeneous immunoassay

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Article information

DOI
https://doi.org/10.1039/C8CC06754F
Article type
Communication
Submitted
20 Aug 2018
Accepted
29 Oct 2018
First published
29 Oct 2018

Chem. Commun., 2018,54, 13103-13106

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Asynchrony of spectral blue-shifts of quantum dot based digital homogeneous immunoassay

X. Liu, C. Huang, X. Dong, A. Liang, Y. Zhang, Q. Zhang, Q. Wang and H. Gai, Chem. Commun., 2018, 54, 13103 DOI: 10.1039/C8CC06754F

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