Issue 95, 2018
From the journal:

Chemical Communications

A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis†

Wei Pan, ORCID logo ‡a   Shaohua Gong,‡a   Yanhua Li,a   Huiwen Zhang,a   Na Li ORCID logo *a  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

Abstract

A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo.

Graphical abstract: A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis

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Article information

DOI
https://doi.org/10.1039/C8CC06796A
Article type
Communication
Submitted
21 Aug 2018
Accepted
06 Nov 2018
First published
06 Nov 2018

Chem. Commun., 2018,54, 13439-13442

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A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis

W. Pan, S. Gong, Y. Li, H. Zhang, N. Li and B. Tang, Chem. Commun., 2018, 54, 13439 DOI: 10.1039/C8CC06796A

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