Issue 93, 2018
From the journal:

Chemical Communications

Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction†

Keying Zhang, ORCID logo ab   Shuting Song,a   Lin Yang,a   Qianhao Min, ORCID logo a   Xingcai Wu*a  and  Jun-Jie Zhu ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: jjzhu@nju.edu.cn, wuxingcai@nju.edu.cn

b Anhui Key Laboratory of Spin Electron and Nanomaterials, School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Anhui 234000, China

Abstract

A microRNA (miRNA) fluorescence (FL) nanoprobe based on PDA-UCNPs@FAM-LLD@AuNPs was developed, which exhibited an enhanced signal for imaging intracellular miRNA by combining double-channel exciting single colour FL (DCESCF) with the target cycling amplification reaction. Through this strategy, normal cells and cancer cells could be successfully discriminated.

Graphical abstract: Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction

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Article information

DOI
https://doi.org/10.1039/C8CC07112H
Article type
Communication
Submitted
01 Sep 2018
Accepted
24 Oct 2018
First published
25 Oct 2018

Chem. Commun., 2018,54, 13131-13134

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Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction

K. Zhang, S. Song, L. Yang, Q. Min, X. Wu and J. Zhu, Chem. Commun., 2018, 54, 13131 DOI: 10.1039/C8CC07112H

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