Issue 86, 2018
From the journal:

Chemical Communications

A ratiometric fluorescent probe for bioimaging and biosensing of HBrO in mitochondria upon oxidative stress†

Hong Huanga  and  Yang Tian ORCID logo *a  

* Corresponding authors

a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China
E-mail: ytian@chem.ecnu.edu.cn

Abstract

A novel ratiometric fluorescent probe with high selectivity and sensitivity was designed and developed for bioimaging and biosensing of HBrO in mitochondria. Using this useful tool with low cytotoxicity and good biocompatibility, it was found that O2˙−-induced oxidative stress triggered the burst of HBrO in mitochondria.

Graphical abstract: A ratiometric fluorescent probe for bioimaging and biosensing of HBrO in mitochondria upon oxidative stress

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Article information

DOI
https://doi.org/10.1039/C8CC07125J
Article type
Communication
Submitted
02 Sep 2018
Accepted
02 Oct 2018
First published
03 Oct 2018

Chem. Commun., 2018,54, 12198-12201

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A ratiometric fluorescent probe for bioimaging and biosensing of HBrO in mitochondria upon oxidative stress

H. Huang and Y. Tian, Chem. Commun., 2018, 54, 12198 DOI: 10.1039/C8CC07125J

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