Issue 87, 2018
From the journal:

Chemical Communications

Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity†

Bing Bai,a   Chenxu Yan,a   Yutao Zhang,a   Zhiqian Guo ORCID logo *a  and  Wei-Hong Zhu ORCID logo a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China
E-mail: guozq@ecust.edu.cn

Abstract

A curcuminoid difluoroboron-based tumor-targeting GGT-activatable fluorescent probe (Glu-DFB-biotin) is designed, which has remarkable characteristics of dual-channel and light-up near-infrared (NIR) fluorescence. Furthermore, Glu-DFB-biotin can differentiate hepatic cancer cells from normal cells and is successfully employed for real-time tracking of endogenous GGT activity in living cells.

Graphical abstract: Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity

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Article information

DOI
https://doi.org/10.1039/C8CC07376G
Article type
Communication
Submitted
11 Sep 2018
Accepted
03 Oct 2018
First published
04 Oct 2018

Chem. Commun., 2018,54, 12393-12396

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Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity

B. Bai, C. Yan, Y. Zhang, Z. Guo and W. Zhu, Chem. Commun., 2018, 54, 12393 DOI: 10.1039/C8CC07376G

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