A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque

Peng Wei; Fengfeng Xue; Yunming Shi; Ross Strand; Hui Chen; Tao Yi

doi:10.1039/C8CC07410K

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A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque†

Peng Wei,^a Fengfeng Xue,^a Yunming Shi,^b Ross Strand,^b Hui Chen

^a and Tao Yi

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China
E-mail: yitao@fudan.edu.cn

^b P&G Technology (Beijing) Co., Ltd., No. 35 Yuan Road, B zone, Shunyi District, Beijing, China

Abstract

We report a F⁻ activated methylene blue (MB) releasing platform for imaging and antimicrobial photodynamic therapy (aPDT). By utilizing this platform, one of the selected probes, FD-F3, displays a remarkable near-infrared fluorescence and absorption increase towards F⁻ with good selectivity and low detection limit. This probe has been successfully applied for visualizing F⁻ and performing F⁻ activated aPDT in naturally grown human plaque biofilms.

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Article information

DOI: https://doi.org/10.1039/C8CC07410K
Article type: Communication
Submitted: 12 Sep 2018
Accepted: 29 Oct 2018
First published: 30 Oct 2018

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Chem. Commun., 2018,54, 13115-13118

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A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque

P. Wei, F. Xue, Y. Shi, R. Strand, H. Chen and T. Yi, Chem. Commun., 2018, 54, 13115 DOI: 10.1039/C8CC07410K

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Chemical Communications

A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque†

Abstract

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A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque

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