A one-dimensional solid-state NMR approach for 14NH/14NH overtone correlation through 1H/1H mixing under fast MAS

Abstract

Homonuclear correlations are key to structural studies using solid-state NMR. In this contribution, using ¹⁴N overtone transition (OT) as a selective excitation approach, we propose a proton-detected one-dimensional (1D) ¹⁴N^OT/¹⁴N^OT/¹H correlation solid-state NMR method mediated through ¹H/¹H mixing at fast magic angle spinning to achieve NH/NH proximities in naturally abundant samples. The proposed method is time efficient by a factor of ∼7.5 in comparison to the existing fundamental ¹⁴N frequency-based three-dimensional (3D) ¹⁴N/¹⁴N/¹H correlation method.