Issue 16, 2018
From the journal:

Dalton Transactions

Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation†

Jingran Dong,‡a   Hongwu Tian,‡a   Changying Song,a   Tiesheng Shi ORCID logo *a  and  Lars I. Elding ORCID logo b  

* Corresponding authors

a College of Chemistry and Environmental Science, and the MOE Key Laboratory of Medicinal Chemistry and Molecular Diagnostics, Hebei University, Baoding 071002, Hebei Province, People's Republic of China
E-mail: rock@hbu.edu.cn

b Center for Analysis and Synthesis, Department of Chemistry, Lund University, POB 124, SE-221 00 Lund, Sweden

Abstract

Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between log kRS− and the thiol dissociation constants pKRSH is disclosed: log kRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.

Graphical abstract: Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

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Article information

DOI
https://doi.org/10.1039/C8DT00852C
Article type
Communication
Submitted
06 Mar 2018
Accepted
26 Mar 2018
First published
27 Mar 2018

Dalton Trans., 2018,47, 5548-5552

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Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

J. Dong, H. Tian, C. Song, T. Shi and L. I. Elding, Dalton Trans., 2018, 47, 5548 DOI: 10.1039/C8DT00852C

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