Issue 10, 2018

Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru–papain conjugate

Abstract

The X-ray structure of an aerated achiral Ru–papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(IV)[double bond, length as m-dash]O species for the second one.

Graphical abstract: Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru–papain conjugate

Supplementary files

Article information

Article type
Paper
Submitted
26 Jun 2018
Accepted
23 Aug 2018
First published
23 Aug 2018

Metallomics, 2018,10, 1452-1459

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