Issue 11, 2018
From the journal:

Organic & Biomolecular Chemistry

O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide†

Yang Geng,a   Mingxiang Zhu,a   Apeng Liang,a   Chengshan Niu,b   Jingya Li,b   Dapeng Zou,*a   Yusheng Wu ORCID logo *abc  and  Yangjie Wu ORCID logo *a  

* Corresponding authors

a The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China
E-mail: zdp@zzu.edu.cn, wyj@zzu.edu.cn
Tel: +86 371 6776 6865

b Tetranov Biopharm, LLC. And Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, P. R. China

c Tetranov International, Inc., 100 Jersey Avenue, Suite A340, New Brunswick, NJ 08901, USA
E-mail: yusheng.wu@tetranovglobal.com
Fax: +1 732 253 7327
Tel: +1 732 253 7326

Abstract

The first O-difluorodeuteromethylation of phenols using commercial diethyl bromodifluoromethylphosphonate and deuterium oxide to prepare various difluorodeuteromethyl aryl ethers is reported. This facile method affords a convenient way to introduce OCF2D groups into organic molecules.

Graphical abstract: O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

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Article information

DOI
https://doi.org/10.1039/C7OB03088F
Article type
Communication
Submitted
13 Dec 2017
Accepted
08 Feb 2018
First published
08 Feb 2018

Org. Biomol. Chem., 2018,16, 1807-1811

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O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

Y. Geng, M. Zhu, A. Liang, C. Niu, J. Li, D. Zou, Y. Wu and Y. Wu, Org. Biomol. Chem., 2018, 16, 1807 DOI: 10.1039/C7OB03088F

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