Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids†
R.
Schettini, 
a
C.
Costabile,
a
G.
Della Sala,
a
P.
Tecilla,
b
M. C.
Vaccaro,
c
I.
Bruno,
c
F.
De Riccardis
a
and
I.
Izzo
*a
a
C.
Costabile,
a
G.
Della Sala,
a
P.
Tecilla,
b
M. C.
Vaccaro,
c
I.
Bruno,
c
F.
De Riccardis
a
and
I.
Izzo
*a
Abstract
Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.
- This article is part of the themed collection: Supramolecular chemistry in OBC
Please wait while we load your content...
