Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

Tianchao Shi; Feng Qin; Qian Li; Wu Zhang

doi:10.1039/C8OB02694G

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Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols†

Tianchao Shi,^a Feng Qin,^a Qian Li^a and Wu Zhang

*^a

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* Corresponding authors

^a Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China
E-mail: zhangwu@mail.ahnu.edu.cn
Fax: +86-553-3869310
Tel: +86-553-3883513

Abstract

An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good functional group tolerance and operational simplicity.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB02694G
Article type: Paper
Submitted: 31 Oct 2018
Accepted: 28 Nov 2018
First published: 29 Nov 2018

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Org. Biomol. Chem., 2018,16, 9487-9491

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Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

T. Shi, F. Qin, Q. Li and W. Zhang, Org. Biomol. Chem., 2018, 16, 9487 DOI: 10.1039/C8OB02694G

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Organic & Biomolecular Chemistry

Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols†

Abstract

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Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

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