Issue 27, 2018

Inhibition of lysozyme's polymerization activity using a polymer structural mimic

Abstract

Hen egg white lysozyme (HEWL) is a green catalyst capable of polymerizing 2-ethynylpyridine. 1,3-di(2-pyridyl)propane (DPP) is a mimic of the polymer repeating unit, and its interaction with HEWL reveals structural insight into the mechanism of polymerization. These interactions were probed using NMR methods, including diffusion-ordered spectroscopy (DOSY) and saturation transfer difference (STD) measurements, and the structure of HEWL with DPP in the active site was elucidated by X-ray methods.

Graphical abstract: Inhibition of lysozyme's polymerization activity using a polymer structural mimic

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2018
Accepted
28 May 2018
First published
29 May 2018

Polym. Chem., 2018,9, 3705-3708

Inhibition of lysozyme's polymerization activity using a polymer structural mimic

D. L. Morris, T. C. Leeper and C. J. Ziegler, Polym. Chem., 2018, 9, 3705 DOI: 10.1039/C8PY00545A

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