Issue 4, 2018

1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans

Abstract

A formal 1,6-conjugated addition-mediated [4 + 1] annulation of ortho-hydroxyphenyl-substituted para-quinone methides with sulfonium or ammonium bromides has been described. This domino-type process offered an efficient method for the synthesis of 2,3-dihydrobenzofurans in good yields, exhibiting good functional group tolerance, scalability and high diastereoselectivity.

Graphical abstract: 1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans

Supplementary files

Article information

Article type
Research Article
Submitted
18 Sep 2017
Accepted
06 Nov 2017
First published
07 Nov 2017

Org. Chem. Front., 2018,5, 623-628

1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans

L. Liu, Z. Yuan, R. Pan, Y. Zeng, A. Lin, H. Yao and Y. Huang, Org. Chem. Front., 2018, 5, 623 DOI: 10.1039/C7QO00846E

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