Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

Abstract

An efficient one-pot approach to the synthesis of α,α-difluoroketone hydrazones has been developed via visible-light photoredox catalysis. The organic dye acts as an inexpensive and non-toxic photocatalyst, and could be recycled in 95% yield in a large-scale synthesis. This reaction occurs under mild conditions with high step-economy, a broad substrate scope, and excellent functional group compatibility. Moreover, the protocol is applicable to the late-stage functionalization of natural products.