Aromatic Pummerer reaction for the remote para- or ortho-benzyl nucleophilic functionalization

Abstract

The classic Pummerer reaction involves an α-substituted sulfide via an elimination/addition of a thionium ion. In this paper, we reported a remote para- or ortho-benzyl nucleophilic functionalization using an aromatic Pummerer process. A plausible mechanism involving a quinone thionium intermediate was proposed to explain this reaction.