Issue 6, 2018
From the journal:

Organic Chemistry Frontiers

Total synthesis and absolute configuration reassignment of mollenines A and B†

Ming-Zhong Wang, ORCID logo *ab   Tong-Xu Si,a   Chuen-Fai Ku,b   Xiao-Wan Li,a   Zheng-Ming Li,c   Hong-Jie Zhang ORCID logo *b  and  Albert S. C. Chan*a  

* Corresponding authors

a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China
E-mail: mzwang2000@163.com, chenxz3@mail.sysu.edu.cn
Fax: +86-(0)20-39943043
Tel: +86-(0)20-39943043

b School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong SAR, PR China
E-mail: zhanghj@hkbu.edu.hk

c State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

The first total synthesis of the indole alkaloids mollenines A and B with the diketomorpholine skeleton has been accomplished in 9 and 10 steps with an overall yield of 11.4% and 9.3%, respectively. The absolute stereochemistry of the two natural products was corrected.

Graphical abstract: Total synthesis and absolute configuration reassignment of mollenines A and B

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Article information

DOI
https://doi.org/10.1039/C7QO00985B
Article type
Research Article
Submitted
30 Oct 2017
Accepted
16 Dec 2017
First published
18 Dec 2017

Org. Chem. Front., 2018,5, 954-957

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Total synthesis and absolute configuration reassignment of mollenines A and B

M. Wang, T. Si, C. Ku, X. Li, Z. Li, H. Zhang and A. S. C. Chan, Org. Chem. Front., 2018, 5, 954 DOI: 10.1039/C7QO00985B

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