Issue 10, 2018

One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(ii)-catalyzed cascade annulation

Abstract

A copper(II)-catalyzed cascade annulation of simple anilines with two molecules of alkyne esters for the one-pot synthesis of 2,4-disubstituted quinolines, with exclusive regioselectivity and excellent substrate/functional group tolerance, is herein described. Moreover, the second molecule of alkyne ester in the reaction was extended to encompass (hetero)aryl- or cycloalkyl-ketone substrates, which further demonstrates the viability of the present Cu(II)-catalyzed system.

Graphical abstract: One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(ii)-catalyzed cascade annulation

Supplementary files

Article information

Article type
Research Article
Submitted
18 Jan 2018
Accepted
26 Mar 2018
First published
27 Mar 2018

Org. Chem. Front., 2018,5, 1713-1718

One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(II)-catalyzed cascade annulation

W. Wu, Y. Guo, X. Xu, Z. Zhou, X. Zhang, B. Wu and W. Yi, Org. Chem. Front., 2018, 5, 1713 DOI: 10.1039/C8QO00052B

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