Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

Abstract

We have developed a Pd-catalyzed direct dehydroxylative cyanation of phenols by employing an inexpensive food additive, potassium ferrocyanide (K₄[Fe(CN)₆]), as the cyanating reagent instead of highly toxic cyanide salts. This protocol provides a strategically distinct approach for the preparation of aryl nitriles in a safe, mild, convenient and practical manner.