Issue 38, 2018, Issue in Progress
From the journal:

RSC Advances

Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex†

Jimmy Erik Jakobsson ORCID logo *a  and  Patrick Johannes Rissabc  

* Corresponding authors

a Realomics Strategic Research Initiative, Department of Chemistry, Faculty for Mathematics and Natural Sciences, University of Oslo, Norway
E-mail: j.e.jakobsson@kjemi.uio.no

b Department of Surgery and Neuroscience, OUS-Rikshospitalet HF, Oslo, Norway

c Norwegian Medical Cyclotron AS, Nydalen, Oslo, Norway

Abstract

We herein report the development of a convenient, regioselective, aromatic fluorination method of hypervalent iodonium ylides for synthesising fluoro-arenes on a preparative scale. This transition metal free, nucleophilic methodology provides good yields for sterically hindered substrates, irrespective of activation. The methodology simplifies reference synthesis for PET imaging.

Graphical abstract: Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex

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Article information

DOI
https://doi.org/10.1039/C8RA03757D
Article type
Paper
Submitted
02 May 2018
Accepted
26 May 2018
First published
11 Jun 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 21288-21291

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Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex

J. E. Jakobsson and P. J. Riss, RSC Adv., 2018, 8, 21288 DOI: 10.1039/C8RA03757D

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