Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens

Shuaibing Zhang; Ying Huang; Shijun He; Heping Chen; Zhenghui Li; Bin Wu; Jianping Zuo; Tao Feng; Jikai Liu

doi:10.1039/C8RA04226H

Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens†

Shuaibing Zhang,^a Ying Huang,^b Shijun He,^c Heping Chen,^a Zhenghui Li,^a Bin Wu,^a Jianping Zuo,*^c Tao Feng

*^a and Jikai Liu*^a

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* Corresponding authors

^a School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China
E-mail: tfeng@mail.scuec.edu.cn, jkliu@mail.kib.ac.cn

^b Leibniz Research Group – Biobricks of Microbial Natural Product Syntheses, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Adolf–Reichwein–Str. 23, 07745 Jena, Germany

^c State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: jpzuo@simm.ac.cn

Abstract

A chemical study of the common species Albatrellus confluens present in Yunnan province, southwest China led to the identification of a pair of epimers named albatredines A (1) and B (2). They feature a natural unprecedented 1,2,4-oxadiazolidin-5-one skeleton. The acyl substitution pattern and complete configurational assignments were deduced from the comparison between experimental and theoretical ¹³C NMR and ECD data, respectively. Bioassay results showed that compound 1 exhibited a weak immunosuppressive activity against the concanavalin A-induced T lymphocyte cell proliferation (IC₅₀ 2.99 μM).

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DOI: https://doi.org/10.1039/C8RA04226H
Article type: Paper
Submitted: 17 May 2018
Accepted: 07 Jun 2018
First published: 02 Jul 2018
This article is Open Access

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RSC Adv., 2018,8, 23914-23918

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Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens

S. Zhang, Y. Huang, S. He, H. Chen, Z. Li, B. Wu, J. Zuo, T. Feng and J. Liu, RSC Adv., 2018, 8, 23914 DOI: 10.1039/C8RA04226H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens†

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Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens

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