Issue 54, 2018, Issue in Progress
From the journal:

RSC Advances

Novel oligopeptide nanoprobe for targeted cancer cell imaging†

Wen-Qiang Ding,a   Si-Yong Qin, ORCID logo *a   Yin-Jia Cheng,a   Yi-Han Maa  and  Ai-Qing Zhang*a  

* Corresponding authors

a College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, P. R. China
E-mail: sy-qin@mail.scuec.edu.cn, aizhang@scuec.edu.cn

Abstract

Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π–π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.

Graphical abstract: Novel oligopeptide nanoprobe for targeted cancer cell imaging

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Article information

DOI
https://doi.org/10.1039/C8RA06034G
Article type
Paper
Submitted
16 Jul 2018
Accepted
27 Aug 2018
First published
03 Sep 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 30887-30893

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Novel oligopeptide nanoprobe for targeted cancer cell imaging

W. Ding, S. Qin, Y. Cheng, Y. Ma and A. Zhang, RSC Adv., 2018, 8, 30887 DOI: 10.1039/C8RA06034G

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