Cobalt(iii)-catalyzed site-selective C–H amidation of pyridones and isoquinolones

Abstract

In this study, Cp*Co(III)-catalyzed site-selective amidation of pyridones and isoquinolones using oxazolones as the amidation reagent is reported. This approach features mild conditions, high efficiency and good functional tolerance. Furthermore, gram-scale preparation and preliminary mechanism experiments were carried out. It provides a straightforward approach for the direct modification of pyridone derivatives.