Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction†
Ekemini D.
Akpan, 
a
Praveen K.
Chinthakindi,
a
Edikarlos M.
Brasil,
a
Kamal K.
Rajbongshi,
a
Thavendran
Govender,
a
Hendrik G.
Kruger,
a
Tricia
Naicker
*a
and
Per I.
Arvidsson
*ac
a
Praveen K.
Chinthakindi,
a
Edikarlos M.
Brasil,
a
Kamal K.
Rajbongshi,
a
Thavendran
Govender,
a
Hendrik G.
Kruger,
a
Tricia
Naicker
*a
and
Per I.
Arvidsson
*ac
Abstract
Herein, we report the preparation of 1,2,4-thiadiazinane 1,1-dioxides from reaction of β-aminoethane sulfonamides with dichloromethane, dibromomethane and formaldehyde as methylene donors. The β-aminoethane sulfonamides were obtained through sequential Michael addition of amines to α,β-unsaturated ethenesulfonyl fluorides followed by further DBU mediated sulfur(VI) fluoride exchange (SuFEx) reaction with amines at the S–F bond.
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