Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids†
Dongbing
Zhao 
*a
and
Qi-Lin
Zhou
a
*a
and
Qi-Lin
Zhou
a
Abstract
Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds.
- This article is part of the themed collection: Celebrating 100 Years of Chemistry at Nankai University
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