Facile synthesis of metal–organic framework-derived SiW12@Co3O4 and its peroxidase-like activity in colorimetric assay

Abstract

Over the past few years, artificial enzymes have attracted enormous attention due to their high stabilities and cost-effective productions. In this work, metal–organic framework-derived SiW₁₂@Co₃O₄ was synthesized in large quantities by stirring the mixture at ambient temperature and calcination. The obtained SiW₁₂@Co₃O₄ exhibited a highly inherent peroxidase-like activity and excellent stability. Kinetic studies demonstrated that the synthesized SiW₁₂@Co₃O₄ had a strong binding affinity to 3,3′,5,5′-tetramethylbenzidine (TMB), stronger than HRP had. Specifically, the peroxidase-like activity of SiW₁₂@Co₃O₄ in an aqueous solution was well maintained after incubation at an elevated temperature, at an extreme pH and for a long time. A SiW₁₂@Co₃O₄-based method was further developed for H₂O₂ and one-pot glucose detection with good sensitivity and reliability. The facile synthesis approach is expected to facilitate the practical use of metal–organic frameworks and their derivatives as enzyme mimics in the future.