Issue 2, 2019

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

Abstract

Here, we report the first synthesis of quasi-stable trimer models of full-length Aβ40 with a toxic conformation using a 1,3,5-phenyltris-L-alanyl linker at position 34, 36, or 38. The only trimer to exhibit weak neurotoxicity against SH-SY5Y cells was the one which was linked at position 38. This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model.

Graphical abstract: Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

Supplementary files

Article information

Article type
Communication
Submitted
28 Oct 2018
Accepted
30 Nov 2018
First published
30 Nov 2018

Chem. Commun., 2019,55, 182-185

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K. Akagi, R. C. Yanagita and K. Irie, Chem. Commun., 2019, 55, 182 DOI: 10.1039/C8CC08618D

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