Solvent-assisted synthesis of a shape-persistent chiral polyaza gigantocycle characterized by a very large internal cavity and extraordinarily high amplitude of the ECD exciton couplet

Abstract

A giant, chiral square-shaped octaimine macrocycle has been obtained in a controlled manner from readily available and inexpensive substrates: 9,10-diphenylanthracene-based dialdehyde and trans-1,2-diaminocyclohexane. Reduction of the polyimine led to a chiral octaamine characterized by a very large internal hydrophobic cavity.