Issue 23, 2019
From the journal:

Chemical Communications

An ROS-responsive and self-accelerating drug release nanoplatform for overcoming multidrug resistance†

Xueming Lv,a   Yiyong Zhu,a   Hamidreza Ghandehari,b   Ao Yu*c  and  Yongjian Wang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
E-mail: yongjian_wang@nankai.edu.cn

b Departments of Pharmaceutics and Pharmaceutical Chemistry, and of Bioengineering, Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA

c College of Chemistry, Nankai University, Tianjin 300071, China
E-mail: esr@nankai.edu.cn

Abstract

An ‘on-demand’ drug release and ROS-responsive nanoparticle was prepared by chemically conjugating hydrophobic α-tocopheryl succinate to hydrophilic poly(ethylene glycol) via a thioketal linker. This nanoparticle encapsulated with doxorubicin and α-tocopheryl succinate exhibited remarkable efficiency in reversing multidrug resistance both in vitro and in vivo.

Graphical abstract: An ROS-responsive and self-accelerating drug release nanoplatform for overcoming multidrug resistance

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Article information

DOI
https://doi.org/10.1039/C9CC00358D
Article type
Communication
Submitted
15 Jan 2019
Accepted
20 Feb 2019
First published
20 Feb 2019

Chem. Commun., 2019,55, 3383-3386

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An ROS-responsive and self-accelerating drug release nanoplatform for overcoming multidrug resistance

X. Lv, Y. Zhu, H. Ghandehari, A. Yu and Y. Wang, Chem. Commun., 2019, 55, 3383 DOI: 10.1039/C9CC00358D

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