Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Dao Le; Friederike Wagner; Masanari Takamiya; I-Lun Hsiao; Gabriela Gil Alvaradejo; Uwe Strähle; Carsten Weiss; Guillaume Delaittre

doi:10.1039/C9CC00407F

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Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly†

Dao Le,

‡^ab Friederike Wagner,‡^ab Masanari Takamiya,^a I-Lun Hsiao,^ac Gabriela Gil Alvaradejo,^ab Uwe Strähle,^a Carsten Weiss^a and Guillaume Delaittre

*^ab

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* Corresponding authors

^a Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
E-mail: guillaume.delaittre@kit.edu

^b Institute for Chemical Technology and Polymer Chemistry (ITCP), Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76128 Karlsruhe, Germany

^c School of Food Safety, College of Nutrition, Taipei Medical University, No. 250, Wuxing St., Taipei 11031, Taiwan

Abstract

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core–shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

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DOI: https://doi.org/10.1039/C9CC00407F
Article type: Communication
Submitted: 16 Jan 2019
Accepted: 21 Feb 2019
First published: 25 Feb 2019
This article is Open Access

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Chem. Commun., 2019,55, 3741-3744

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Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

D. Le, F. Wagner, M. Takamiya, I. Hsiao, G. Gil Alvaradejo, U. Strähle, C. Weiss and G. Delaittre, Chem. Commun., 2019, 55, 3741 DOI: 10.1039/C9CC00407F

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Chemical Communications

Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly†

Abstract

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Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

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